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Tuberculosis vaccine target found Print E-mail
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พฤหัสบดี, 24 มีนาคม 2011


Researchers are trying to find new proteins which can be used in a vaccine to trigger an immune response and provide long-term protection against Mycobacterium tuberculosis.

The study, to be published in Proceedings of the National Academy of Sciences, identifies a new protein called EspC.

Professor Lalvani said: "We've shown that EspC, which is secreted by the bacterium, provokes a very strong immune response, and is also highly specific to Mycobacterium tuberculosis. This makes it an extremely promising candidate for a new TB vaccine that could stimulate broader and stronger immunity than BCG."

Consultant chest physician Dr Peter Davies, who is the secretary of TB Alert, said it was "promising" research.

He told the BBC: "We know of two other targets and the researchers have found a third, which could be useful.

"The trouble is it will take 10 years to find out if it will result in vaccine and whether that vaccine is any better than BCG."

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