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The Effect of a Low-Fat, High-Protein or High-Carbohydrate Ad Libitum Diet on Weight Loss Print E-mail
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เสาร์, 09 พฤษภาคม 2009

Maintenance and Metabolic Risk Factors: A Must Read From F1000


Mikael FogelholmPublished: 04/24/2009Claessens M, van Baak MA, Monsheimer S, Saris WH
Int J Obes (Lond) 2009 Mar 33(3):296-304

Commentary from Mikael Fogelholm Changes Clinical Practice: High-protein diets should be considered more often in weight reduction programs.

This randomized clinical trial show that weight maintenance during 12 weeks after a 5-week very-low-energy diet was better in participants eating a high-protein, moderate-carbohydrate diet, compared to a moderate-protein, high-carbohydrate diet. The type of protein (fast or slow absorption) did not have an effect on weight maintenance. The study extends the results, showing a beneficial effect of protein from the weight loss phase to the period after this phase.


Earlier studies have shown that high-protein diets may induce better weight reduction compared to high-carbohydrate diets. This effect has been linked to the satiety effects of protein and to the high metabolic cost of metabolizing protein. Moreover, preliminary studies have suggested that the type of protein (fast absorption, such as whey, vs. slow absorption, such as casein) could have an effect on satiety and perhaps on weight reduction. The diet composition (as % in energy intake) in the present study was as follows: high-protein, moderate-carbohydrate diet: protein 35%, carbohydrate 42%, fat 24%; moderate-protein, high-carbohydrate diet: protein 16%, carbohydrate 63%, fat 21%. Moreover, the high-protein participants were divided into casein-enriched and whey-enriched groups. The combined high-protein groups lost about 1kg during the 12-week intervention period, whereas the high-carbohydrate group gained an approximately equal amount. No time-by-treatment effect was observed when comparing the two protein groups. The focus on weight maintenance period after weight loss was the new aspect and strength in the present study. Moreover, the comparison of two different types of proteins was new and interesting, despite negative results. The short time frame was a limitation: future studies should use longer interventions and/or follow the participants for at least 1 year after the intervention. It would also be important to compare the long-term effects on weight maintenance of high-protein, moderate carbohydrate, low-fat diets with high-protein, high-fat, low-carbohydrate diets.

 Faculty of 1000 Medicine Evaluations, Dissents and Author responses for: [Claessens M et al. The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors. Int J Obes (Lond) 2009 Mar 33(3):296-304]. 2009 Apr 14 www.f1000medicine.com/article/id/1158795/evaluation
Last Updated ( ศุกร์, 08 พฤษภาคม 2009 )
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